Generalized hyperpigmentation after pyrimethamine use

Postinflammatory Hyperpigmentation After Skin Prick Testing

To the Editor: Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis, which occurs after inflammation, trauma, or therapeutic interventions. PIH presents as irregular darkly pigmented macules that can persist for months or even years. PIH occurs more frequently in the darker Fitzpatrick skin types IV to VI, for instance, found in individuals from Africa, Asia, and South America...

Postinflammatory hyperpigmentation after human cold pain testing

Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to meas...

Reversible generalized cutaneous hyperpigmentation: presenting manifestation of pernicious anemia.

A 16-year-old boy presented with progressive and asymptomatic mottled hyperpigmentation that had been there for four years. The lesions had appeared initially on his arms and extended gradually over the years to involve the trunk, face, and extremities (Fig. 1). The palms and soles were prominently involved, and fingernails showed longitudinal hyperpigmented streaks (Fig. 2). The mucous membran...

Extrapyramidal syndrome after treatment of falciparum malaria with sulphadoxine-pyrimethamine.

Hyperpigmentation and chikungunya fever*